CLASTOGENICITY OF LABORATORY MIXTURE OF LINDANE AND CARBARYL IN MICE

Published on Oct 07, 2019 10:44 AM

A laboratory mixture of two insecticides, viz., carbaryl and lindane (1:1) was tested
for its clastogenicity qt the bone marrow erythrocytes of swiss albino mice. The
insecticidal mixture was injected intraperitoneally at three dose levels as a suspension
in 1% gum acacia, and chromosome aberrations assay and micronucleus test were
performed in both sexes separately. Ethylmethanesulphonate (EMS) was taken as
positive reference mutagen. An increase in the frequency of micronucleated
erythrocytes was observed following treatment with the test chemical mixture.· In
chromosome aberrations assay, a significant induction was observed at 185 mglkg
bw. at 24h post-treatment time. The female mice appear more tolerant to the test
mixture than the male mice.

Keywords: Clastogenicity, lindane, carbaryl,. mice, micronuclei, chromosome aberrations, erythrocytes

Info

Year: 1998
Volume: 58
Issue: 4
Article DOI: NA
Print ISSN: 0019-5200
Online ISSN: 0975-6906

Authors

SUDHIR CHANDNA, P. K. SAREEN, R. P. SAHARAN AND J. B. CHOWDHARY

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