A cross sectional samples of 515 marriages of the Muslims of Alappuzha district
of the state of Kerala were studied for estimating the component of geneiic load
operating in the prenatal and postnatal stages. Consanguinity-associated prenatal
and postnatal mortality was found to be 4.84 to 5.07 times higher than control. The
genetic burden manifested in total prereproductive mortality in the group was
estimated between 3.1009 and 3.1379 lethal equivalents per gamete. It suggests that
a normal 'healthy' human being carries in heterozygote condition 7 lethal equivalent
genes, if made homozygyous, they would kill an individual between birth and
maturity. The high BfA ratio (83.74) is suggestive that mortality disclosed by
. inbreeding in this group is predominantly from mutational load.
Keywords: Muslim, consanguinity, mortality, genetic load.
Article DOI: NA
Print ISSN: 0019-5200
Online ISSN: 0975-6906
M. V. SUDHAKARAN AND B. VIJAYAVALLI info_circle